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Prognosis prediction of α-FAtE score for locoregional immunotherapy in hepatocellular carcinoma.

Zehao Zheng^1,2,3, Renguo Guan⁴, Rongce Zhao^1,2,3

¹Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.

Frontiers in Immunology

|January 27, 2025

Summary

This summary is machine-generated.

The α-FAtE score predicts outcomes for hepatocellular carcinoma (HCC) patients undergoing locoregional immunotherapy. A lower score indicates better overall survival and progression-free survival, with fewer adverse events.

Keywords:

alkaline phosphatase alpha-fetoprotein eosinophil hepatocellular carcinoma immunotherapy locoregional therapy

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Area of Science:

Hepatobiliary Cancers
Oncology
Immunotherapy

Background:

The alpha-fetoprotein, alkaline phosphatase, and eosinophil (α-FAtE) score has shown prognostic value in HCC patients treated with atezolizumab plus bevacizumab.
Locoregional immunotherapy is a treatment modality for HCC patients.

Purpose of the Study:

To evaluate the predictive performance of the α-FAtE score for the efficacy and safety of locoregional immunotherapy in HCC patients.
To determine if the α-FAtE score can stratify HCC patients for treatment planning.

Main Methods:

Retrospective analysis of 446 HCC patients treated between January 2019 and January 2023.
Predictive performance assessed using concordance index, ROC curve analysis, Kaplan-Meier curves, and Cox regression.
Patients categorized into α-FAtE score groups 0-1 and 2-3.

Main Results:

Patients with a higher α-FAtE score (2-3) demonstrated significantly longer median progression-free survival (12.3 months) and overall survival (34.1 months) compared to those with a lower score (0-1) (PFS: 7.3 months, OS: 16.3 months; P<0.001).
The higher α-FAtE score group exhibited a higher complete response rate and experienced fewer drug-related adverse events.
A lower α-FAtE score was identified as an independent prognostic indicator for both OS and PFS in advanced HCC patients receiving locoregional immunotherapy.

Conclusions:

The α-FAtE score is a robust predictor of prognosis in HCC patients undergoing locoregional immunotherapy.
This score can serve as a valuable tool for stratifying patients and guiding treatment decisions in HCC management.