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Harnessing Extracellular Vesicles for Stabilized and Functional IL-10 Delivery in Macrophage Immunomodulation

Najla A Saleh1, Matthew A Gagea1,2, Xheneta Vitija1,3

  • 1Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, Michigan, USA.

Biorxiv : the Preprint Server for Biology
|January 27, 2025
PubMed
Summary

Engineered extracellular vesicles (EVs) efficiently deliver interleukin-10 (IL-10) for enhanced stability and immune modulation. Naïve EVs also show anti-inflammatory effects, highlighting complex EV functions.

Keywords:
Extracellular vesiclesexosome purificationimmunomodulationinterleukin-10macrophage polarizationsmall extracellular vesicles

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