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Related Experiment Video

Updated: May 30, 2025

Introducing Shear Stress in the Study of Bacterial Adhesion
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Kinking and buckling instability in growing bacterial chains.

Sean G McMahon, John C Neu, Jing Chen

    Biorxiv : the Preprint Server for Biology
    |January 27, 2025
    PubMed
    Summary

    Bacterial chains use growth force for sliding motility. Models reveal how chain kinking or buckling limits speed and causes breakage, offering insights into optimizing bacterial movement.

    Area of Science:

    • Microbiology
    • Biophysics
    • Theoretical Biology

    Background:

    • Gram-positive bacteria like *Bacillus subtilis* and *Clostridium* species exhibit chain-mediated sliding motility.
    • This motility is driven by the mechanical force of cell growth, with cells forming long chains.
    • While seemingly efficient, mechanical stress can limit motility speed due to chain breakage.

    Purpose of the Study:

    • To develop models explaining how mechanical stress affects bacterial chains.
    • To investigate the mechanisms of chain kinking and buckling under stress.
    • To predict how these deformations influence chain breakage and sliding efficiency.

    Main Methods:

    • Development of theoretical models for growing bacterial chains.
    • Simulation of mechanical stress accumulation and deformation (kinking/buckling).

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  • Analysis of the relationship between chain morphology and breakage susceptibility.

    • Main Results:

    • Models show bacterial chains can form sharp kinks or smooth buckles under stress.
    • These deformations are dependent on specific conditions and bacterial species.
    • Kinking and buckling were shown to significantly affect the chain's susceptibility to breakage.

    Conclusions:

    • The study provides a theoretical framework for understanding bacterial sliding motility dynamics.
    • Chain kinking and buckling represent mechanical limitations to motility speed.
    • Identifying optimal cell properties can enhance the efficiency of this bacterial movement mechanism.