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Drug Therapy01:28

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Medication Use Quality and Safety in Older Adults: 2023 Update.

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This review highlights four key 2023 studies on medication safety and optimization in older adults. It covers deprescribing, prescribing cascades, drug interactions, and adverse events to improve medication use.

Keywords:
ageddeprescribinginappropriate prescribingmedication‐related problemspolypharmacy

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Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Health Services Research

Background:

  • Medication use and safety are critical for older adults.
  • Optimizing medication regimens is essential for this population.
  • Identifying high-quality research advances this field.

Purpose of the Study:

  • To identify and review four exemplary studies from 2023 focused on improving medication use and safety in older adults.
  • To cover key domains including deprescribing, medication optimization, and adverse drug events.

Main Methods:

  • Review of four high-quality studies published in 2023.
  • Included a randomized clinical trial on deprescribing.
  • Included retrospective cohort studies and a systematic review/meta-analysis.

Main Results:

  • A patient-centered deprescribing intervention showed efficacy in older adults transitioning care.
  • A prescribing cascade relic involving potassium use was identified.
  • High prevalence of drug-drug interactions in community-dwelling older adults was noted.
  • Concurrent gabapentin and opioid use was linked to increased mortality risk.

Conclusions:

  • These studies underscore the importance of deprescribing and optimizing medication use in older adults.
  • Awareness of prescribing cascades and drug-drug interactions is crucial for safety.
  • Research highlights the need for vigilance regarding specific medication combinations and mortality risk.