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Dementia

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....

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Related Experiment Video

Updated: May 30, 2025

A Method for Quantifying Upper Limb Performance in Daily Life Using Accelerometers

A Method for Quantifying Upper Limb Performance in Daily Life Using Accelerometers

Published on: April 21, 2017

Accelerometer-measured physical activity timing with incident dementia.

Yuye Ning¹, Meilin Chen¹, Hao Yang¹

¹Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|January 27, 2025

Summary

Engaging in moderate to vigorous physical activity (MVPA) in the morning is linked to a reduced risk of dementia and Alzheimer's disease. Optimal timing for physical activity may play a role in dementia prevention strategies.

Keywords:

Alzheimer's disease accelerometer‐measured physical activity dementia epidemiology public health

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Last Updated: May 30, 2025

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Published on: March 7, 2019

Area of Science:

Neuroscience
Public Health
Gerontology

Background:

Moderate to vigorous physical activity (MVPA) is associated with a reduced risk of dementia.
The optimal timing of MVPA for dementia prevention remains unclear.

Purpose of the Study:

To investigate the association between the timing of accelerometer-measured MVPA and the risk of developing dementia.
To determine if specific times of day for MVPA are more beneficial for cognitive health.

Main Methods:

Utilized accelerometer data from 90,329 UK Biobank participants.
Assessed MVPA patterns (morning, afternoon, evening, mixed, inactive) over at least 2 years of follow-up.
Employed multivariable-adjusted Cox proportional hazards models to analyze dementia risk.

Main Results:

Morning MVPA was associated with a significantly lower risk of all-cause dementia (HR: 0.60) and Alzheimer's disease (HR: 0.44) compared to being inactive.
No significant associations were observed between MVPA at other times of day and all-cause dementia risk.
MVPA timing did not show a significant relationship with the incidence of vascular dementia.

Conclusions:

Morning MVPA is linked to a reduced risk of all-cause dementia and Alzheimer's disease.
MVPA timing does not appear to influence vascular dementia risk.
Findings suggest that timing-specific physical activity interventions could be a novel strategy for dementia prevention.