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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Emerging Frontiers in Colorectal Cancer Therapy: From Targeted Molecules to Immunomodulatory Breakthroughs and

Nayeralsadat Fatemi1, Seyedeh Nasim Mirbahari1,2,3, Sascha Tierling4

  • 1Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Digestive Diseases and Sciences
|January 27, 2025
PubMed

Insights

Colorectal cancer (CRC) treatments are advancing with new therapies like CAR-T cell therapies and immune checkpoint inhibitors. This review explores innovative options to improve outcomes for CRC patients facing limited conventional choices.

Area of Science:

  • Oncology
  • Cancer Therapeutics
  • Immunotherapy

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide.
  • Existing therapeutic strategies for CRC require significant advancements.
  • Novel treatment modalities are emerging to address unmet clinical needs.

Purpose of the Study:

  • To provide a comprehensive review of cutting-edge therapies for colorectal cancer.
  • To explore advancements in targeted molecular therapies, immunomodulatory agents, and cell-based therapies.
  • To evaluate the potential of innovative treatments to improve patient outcomes and reshape the CRC treatment landscape.

Main Methods:

  • Review of recent clinical trials and scientific literature.
  • Analysis of targeted molecular therapies, including genetic and molecular profiling.
  • Evaluation of immunomodulatory agents and cell-based therapies, such as chimeric antigen receptor-T (CAR-T) cell therapies and oncolytic viruses.

Main Results:

  • Emergence of transformative therapies including CAR-T cell therapies, oncolytic viruses, and immune checkpoint inhibitors.
  • These innovative treatments offer personalized approaches based on individual patient profiles.
  • Potential for enhanced patient outcomes and improved efficacy compared to conventional options.

Conclusions:

  • Innovative therapies hold significant promise for improving colorectal cancer treatment.
  • Further research and clinical trials are essential to optimize these novel approaches.
  • A new era of personalized and effective CRC therapy is on the horizon.
Keywords:
CAR-T-cell therapiesColorectal cancerImmune checkpoint inhibitorsOncolytic virusesTargeted molecular therapies

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