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Hidradenitis Suppurativa.

S McCarthy1

  • 1Division of Dermatology, University College Cork, The National University of Ireland, Cork, Ireland;

Annual Review of Medicine
|January 27, 2025
PubMed
Summary
This summary is machine-generated.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition impacting quality of life. While current treatments offer partial response, new therapies targeting immune pathways show promise for improved efficacy.

Keywords:
acne inversahidradenitis suppurativa

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting intertriginous areas.
  • HS presents with nodules, abscesses, and fistulae, significantly impacting patient quality of life due to pain and suppuration.
  • The exact cause of HS is unknown, with current hypotheses involving genetics, immune system dysregulation, and environmental factors.

Purpose of the Study:

  • To provide an overview of hidradenitis suppurativa, including its clinical presentation, pathogenesis, and management.
  • To discuss the current therapeutic landscape and emerging treatments for HS.
  • To highlight the challenges in managing this complex dermatological condition.

Main Methods:

  • Literature review of hidradenitis suppurativa etiology, pathogenesis, and treatment.
  • Analysis of current therapeutic options, including approved biologics.
  • Examination of ongoing clinical trials for novel HS therapies targeting specific immune pathways.

Main Results:

  • HS affects an estimated 0.05% to 4.1% of the population, with higher prevalence in females.
  • Approved biologic therapies provide clinical response in about 50% of HS patients.
  • Emerging therapies targeting IL-1, IL-17, IL-36, and JAK/STAT pathways are under investigation.

Conclusions:

  • Hidradenitis suppurativa is a complex, multifactorial disease with significant unmet needs.
  • Current biologic therapies offer moderate efficacy, necessitating further research.
  • Investigational therapies targeting key inflammatory pathways hold promise for future HS management.