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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: May 30, 2025

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

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Published on: February 9, 2021

Synergistic Cancer Photoimmunotherapy by Harnessing Near-Infrared-Activated Nanoparticles Containing Charge Transfer

Aaron J Lim¹, Kade P Littlefield¹, Zaid Alkalani¹

¹Department of Chemistry and Biochemistry, The University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.

Angewandte Chemie (International Ed. in English)

|January 27, 2025

Summary

This study introduces a novel nanoparticle for photoimmunotherapy (PIT) by integrating donor-acceptor interactions. This approach shows potent anti-cancer effects, combining photothermal therapy (PTT) and photodynamic therapy (PDT) with immunotherapy.

Keywords:

Biocompatible nanoparticles Charge transfer complexes Donor–acceptor interactions Heavy atom effect Photoimmunotherapy

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Area of Science:

Oncology
Nanotechnology
Immunotherapy

Background:

Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is a promising cancer treatment due to its precision and minimal side effects.
Integrating immunotherapy with physical therapies offers a synergistic approach to cancer treatment.

Purpose of the Study:

To develop and evaluate a novel near-infrared-activated charge transfer complex-based nanoparticle for photoimmunotherapy (PIT).
To investigate the synergistic anti-cancer effects of combining this nanoparticle with programmed cell death protein 1 (PD-1) antibody therapy.

Main Methods:

Fabrication of a donor-acceptor (D-A) based nanoparticle activated by near-infrared light.
Evaluation of the nanoparticle's efficacy in preclinical cancer models, including combination with PD-1 antibody therapy.

Main Results:

The developed D-A nanoparticle demonstrated potent immunotherapeutic effects in preclinical models.
The integration of D-A interactions into nanosystems for PIT represents a novel and effective strategy.

Conclusions:

The novel D-A nanoparticle-based photoimmunotherapy holds significant promise for synergistic cancer treatment.
This approach offers a multifaceted strategy with the potential to transform cancer treatment paradigms.