Age-Related Arterial Stiffening Is Associated with a Body Shape Index and Lean Body Mass Index: A Retrospective Cohort Study in Healthy Japanese Population
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View abstract on PubMed
Summary
This summary is machine-generated.The body shape index (ABSI) reflects age-related arterial stiffness and lean body mass changes. Monitoring ABSI and cardio-ankle vascular index (CAVI) may help manage the vicious cycle of arterial stiffening and muscle loss.
Area Of Science
- Cardiovascular Health
- Gerontology
- Body Composition Analysis
Background
- Arterial stiffness is a marker of cardiovascular risk, but its relationship with body composition changes over time is not fully understood.
- Existing anthropometric indices have limitations in reflecting cardiometabolic risks.
- Age-related changes in body composition and their impact on arterial stiffness require further investigation.
Purpose Of The Study
- To investigate the association between aging, body composition indices, and arterial stiffness.
- To determine the mediating role of anthropometric indices in the relationship between age and arterial stiffness.
- To explore the interaction between age-related changes in body composition and the progression of arterial stiffness.
Main Methods
- Analysis of cross-sectional (N=13,672) and longitudinal (N=5,118) data from a healthy Japanese population.
- Examination of relationships between age and anthropometric indices: estimated lean body mass index (eLBMI), body mass index (BMI), waist circumference (WC), and body shape index (ABSI).
- Assessment of arterial stiffness using cardio-ankle vascular index (CAVI) and analysis of mediating effects on age-CAVI association.
Main Results
- ABSI and CAVI demonstrated a positive linear relationship with aging.
- Lean body mass (eLBMI) showed a declining trend with aging, particularly in middle-older age groups.
- Increased ABSI was linked to decreased eLBMI, while increased BMI/WC correlated with increased eLBMI. Age-related CAVI was partially mediated by ABSI and eLBMI.
Conclusions
- The body shape index (ABSI) is a modifiable indicator reflecting age-related arterial stiffness and body composition, including lean body mass.
- Arterial stiffening may contribute to skeletal muscle loss, potentially creating a detrimental cycle.
- Clinical monitoring of CAVI and anthropometric indices like ABSI is recommended to manage this cycle.
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