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Related Concept Videos

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Related Experiment Video

Updated: Jun 30, 2026

Diffusion Imaging in the Rat Cervical Spinal Cord
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The apparent diffusion coefficient color Map for evaluating a large ischemic core.

Takeru Umemura1, Yuko Tanaka2, Toru Kurokawa2

  • 1Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Japan.

Journal of Neuroradiology = Journal De Neuroradiologie
|January 27, 2025
PubMed
Summary

An apparent diffusion coefficient (ADC) color map visualizes ischemic stress in stroke patients. A high ratio of salvageable tissue (ADC520) indicates potential for successful endovascular treatment (EVT).

Keywords:
Apparent diffusion coefficientDiffusion-weighted imagingEndovascular treatmentLarge ischemic coreLarge ischemic stroke

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Previous research linked apparent diffusion coefficient (ADC) values to endovascular treatment (EVT) outcomes in large ischemic strokes.
  • Higher peak ADC values (≥520×10-6 mm2/s) correlated with better clinical results.
  • ADC reduction severity reflects ischemic stress, prompting the need for better visualization methods.

Purpose of the Study:

  • To assess the utility of an ADC color map in visualizing ischemic stress.
  • To determine if ADC color mapping can aid in predicting EVT outcomes.
  • To identify factors associated with higher peak ADC values in patients with low ASPECTS.

Main Methods:

  • Retrospective cohort study of patients with low Alberta Stroke Program Early Computed Tomography Score (ASPECTS) undergoing successful EVT.
  • Development of an ADC color map by assigning colors to DWI lesions based on ADC values (≥520, 520-440, <440×10-6 mm2/s).
  • Comparison of patients with peak ADC ≥520×10-6 mm2/s versus those with lower peak ADC.

Main Results:

  • 34 out of 78 patients had a peak ADC ≥520×10-6 mm2/s.
  • An ADC520/DWI ratio >60% optimally discriminated between patients with and without a peak ADC ≥520×10-6 mm2/s.
  • This ratio achieved 86% sensitivity and 82% specificity.

Conclusions:

  • ADC color map effectively visualizes the depth of ischemic stress.
  • A large ischemic core with an ADC520/DWI ratio >60% may be salvageable with EVT.
  • This visual approach aids in assessing EVT suitability for acute large ischemic stroke.