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Statin Use Is Associated With Decreased Venous Thromboembolism Events Following Total Hip Arthroplasty: A Matched
Rae Lan1, Neel Vallurupalli1, Vinay K Aggarwal1
1Department of Orthopedic Surgery, NYU Langone Health, New York, New York.
Background:
Despite advances in surgical techniques and postoperative prophylactic protocols, venous thromboembolism (VTE) events remain an important source of morbidity following total hip arthroplasty (THA). Prior research in cardiology and other surgical fields has suggested that statin medications may have a protective effect against VTE. Our study aimed to: (1) assess if preoperative statin use was associated with decreased rates of VTE following THA; and (2) conduct a subgroup analysis of statin intensity and VTE events.
Methods:
A total of 1,154 patients who had preoperative statin use for at least four weeks before surgery and who underwent primary THA at a large, urban academic center between January 1, 2012, and June 1, 2023, were identified. The 90-day postoperative VTE events, deep vein thrombosis, pulmonary embolism, emergency department visits, reoperations, and readmission rates were collected from institutional coding software. Mortality rate in the 90-day postoperative period was also measured. Propensity matching was used to control for demographics and selected comorbidities.
Results:
Preoperative statin use was associated with significantly lower rates of 90-day VTE events (Statin: 0.43% versus No-Statin: 1.13%, P = 0.047). There were no significant differences in 90-day PE, deep vein thrombosis, emergency department visit, readmission, or reoperation rates. There were no deaths within 90 days of THA in either group. Subgroup analysis of statin intensity revealed no significant differences in any outcomes measured between high-intensity, medium-intensity, and low-intensity statin groups.
Conclusions:
Preoperative statin use is associated with significantly lower rates of VTE events in the 90-day postoperative period following THA. Further research into the effect of statins on post-THA VTE is warranted.
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