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Related Experiment Video

Updated: May 30, 2025

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From Circuits to Lifespan: Translating Mouse and Human Timelines with Neuroimaging-Based Tractography.

Nicholas C Cottam1, Kwadwo Ofori1, Kevin T Stoll2

  • 1Department of Biological Sciences, Delaware State University, Dover, Delaware 19901.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|January 27, 2025
PubMed
Summary

Comparing human and mouse development, this study found that white matter maturation extends in both species but with mouse-specific adaptations. A P3-4 mouse brain corresponds to a human at GW24, and a P60 mouse to a human teenager.

Keywords:
Translating Timediffusionhumanmousepathwaystime

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Comparative Biology

Background:

  • Animal models are crucial for studying development and disease, but species-specific developmental paces hinder direct comparisons.
  • Existing tools lack comprehensive age alignments between humans and model organisms like mice across their lifespans.

Purpose of the Study:

  • To establish cross-species age alignments between humans and mice, focusing on developmental timelines.
  • To compare brain circuit maturation, particularly white matter pathways, between humans and mice.
  • To identify commonalities and species-specific adaptations in developmental trajectories.

Main Methods:

  • Utilized the 'Translating Time' resource, incorporating 1,125 observations of age-related changes (body, bone, dental, brain).
  • Acquired high-resolution diffusion MRI scans of 16 mouse brains across postnatal development (P3, P4, P12, P21, P60).
  • Tracked maturation of brain circuits, including olfactory association and transcallosal pathways.

Main Results:

  • Identified heterogeneous white matter pathway growth, with corpus callosum growth ceasing early and olfactory pathways extending to P60.
  • Established age equivalencies: P3-4 mouse ≈ GW24 human; P60 mouse ≈ human teenager.
  • Demonstrated protracted olfactory pathway development in mice, linked to their reliance on olfaction.

Conclusions:

  • White matter maturation is prolonged in both mice and humans, but with distinct species-specific patterns.
  • Translational tools are essential for mapping conserved and unique biological processes from animal models to humans.
  • Findings highlight the importance of considering species-specific adaptations in developmental research.