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Updated: May 30, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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TNIP1 Impacts Prognosis by Modulating the Immune Microenvironment in BRCA.

Dong Liao1, Wu Liu1, Yunhui Jiang2

  • 1Department of Thyroid and Breast Surgery, Jingmen People's Hospital, JingChu University of Technology Affiliated Jingmen People's Hospital, No.39 Xiangshan Road Dongbao Zone, Jingmen, 448000, China.

Biochemical Genetics
|January 27, 2025
PubMed
Summary
This summary is machine-generated.

TNIP1 is underexpressed in breast invasive carcinoma (BRCA) and linked to poor prognosis. This immune signaling molecule correlates with the tumor microenvironment and immune cells, suggesting its potential as a prognostic marker and therapeutic target for BRCA.

Keywords:
TNIP1BRCAPrognosisTME

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Area of Science:

  • Oncology
  • Immunology
  • Genetics

Background:

  • Breast invasive carcinoma (BRCA) remains a significant global health challenge with suboptimal patient outcomes despite treatment advancements.
  • TNIP1, a novel immune signaling pathway regulator, influences tumor progression, but its role in BRCA is not well understood.

Purpose of the Study:

  • To investigate the expression levels of TNIP1 in BRCA tissues.
  • To determine the prognostic value of TNIP1 in BRCA patients.
  • To explore the association between TNIP1 expression and the BRCA tumor microenvironment (TME) and immune cell infiltration.

Main Methods:

  • Bioinformatic analysis of TCGA, GEO, Sangerbox, and Ualcan databases for TNIP1 expression and prognostic significance.
  • Validation using RT-PCR and immunohistochemistry.
  • In-depth analysis of TME components, immune cell infiltration, and immune checkpoint markers using various computational algorithms (e.g., EPIC, TIMER, MCPCounter) and single-cell datasets (TISCH).

Main Results:

  • TNIP1 was found to be underexpressed in BRCA tissues compared to normal tissues.
  • Low TNIP1 expression correlated with poor prognosis in BRCA patients.
  • TNIP1 expression positively correlated with TME scores (StromalScore, ImmuneScore, ESTIMATEScore) and increased infiltration of various immune cells.
  • TNIP1 expression was associated with immune checkpoint markers and showed higher levels in immune cells within the BRCA TME.
  • TNIP1 expression correlated positively with inflammation and differentiation, and negatively with stemness and invasion in BRCA.

Conclusions:

  • TNIP1 is underexpressed in BRCA and serves as a potential marker for poor prognosis.
  • TNIP1 plays a significant role in modulating the immune landscape of the BRCA tumor microenvironment.
  • TNIP1 represents a promising therapeutic target for improving outcomes in breast invasive carcinoma.