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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

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Published on: November 7, 2013

Dual-driven biodegradable nanomotors for enhanced cellular uptake.

Jianhong Wang¹, Andreas Polyviou¹, Jari F Scheerstra¹

¹Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands. J.Shao@tue.nl.

Journal of Materials Chemistry. B

|January 28, 2025

Summary

This study introduces novel hybrid nanomotors that use dual propulsion methods for enhanced biomedical applications. These nanomotors, driven by near-infrared light and catalytic reactions, show improved accumulation in tumor cells.

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Area of Science:

Biomedical Engineering
Nanotechnology
Materials Science

Background:

Hybrid nanomotors offer controllable locomotion for biomedical applications.
Current nanomotors often rely on single propulsion modes, limiting efficiency in complex biological environments.
Dual stimuli-responsive nanomotors can enhance motility and targeting in vivo.

Purpose of the Study:

To develop a hybrid nanomotor with dual propulsion mechanisms for improved biomedical applications.
To investigate the combined effects of plasmonic heating and catalytic conversion for nanomotor actuation.
To enhance nanomotor accumulation within tumor cells for targeted delivery.

Main Methods:

Functionalization of biodegradable stomatocytes with platinum nanoparticles (Pt NPs).
Utilizing near-infrared (NIR) laser irradiation for plasmonic heating and temperature gradient generation.
Employing Pt NPs' catalytic properties to convert hydrogen peroxide (produced from glucose oxidase) into oxygen and water for chemical gradient propulsion.

Main Results:

The hybrid nanomotors demonstrated dual propulsion mechanisms, responding to both NIR laser and chemical stimuli.
Asymmetric stomatocyte shape combined with Pt NPs created effective temperature gradients for propulsion.
Co-encapsulation of glucose oxidase enabled local hydrogen peroxide production, driving catalytic propulsion.
Enhanced accumulation of nanomotors within tumor cells was observed due to their motile features.

Conclusions:

The developed hybrid nanomotors exhibit versatile dual stimuli-responsive locomotion.
This design offers a promising approach for more effective nanocarrier operation in complex biomedical settings.
The nanomotors show potential for enhanced targeted delivery and accumulation in tumor cells.