Related Experiment Video
Updated: May 5, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
Factors Influencing Pregnant Women's Participation in Randomised Clinical Trials in India: A Qualitative Study
Mridula Shankar1, Umesh Charantimath2, Ashwini Dandappanavar2
1Gender and Women's Health Unit, Nossal Institute for Global Health, School of Population and Global Health, University of Melbourne, Carlton, Victoria, Australia.
Objective:
To explore factors affecting participation of pregnant women in randomised clinical trials in Belagavi, Karnataka, India.
Design:
A qualitative study using semi-structured in-depth interviews and focus group discussions as data collection methods.
Setting:
Primary, secondary and tertiary health facilities and their community catchment areas in Belagavi district.
Sample:
Thirty-three in-depth interviews with health workers and previous participants of a pregnancy-focused trial, and 12 focus group discussions with currently pregnant women who had not previously participated in a clinical trial, family and community members, and accredited social health activists.
Methods:
Inductive thematic analysis with a team-based approach to interpretation in the study context.
Results:
Pregnant women were often unable to distinguish between maternal health programmes and trial interventions. Among previous trial participants, expectations of higher quality care were a key motivation for trial participation. Household gendered power relations and trust in the health workforce influenced decisional dynamics regarding participation. Health workers vouched for trial safety, once they assessed the intervention as acceptable. Trial Implementation by the health workforce required understanding and navigating pregnancy-related beliefs and practices in communities.
Conclusion:
Anticipated health benefits, improved healthcare access, and trust in health workers are facilitators of trial participation. Engaging primary decision-makers is essential due to household gender dynamics. Trials must integrate strategies that clarify the distinct goals of research versus clinical care.
More Related Videos
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
09:33Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
Published on: December 23, 2022
Related Concept Videos
Regression Toward the Mean
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Factors Affecting Drug Response: Overview
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Factors Influencing Drug Absorption: Pharmaceutical Parameters