Related Experiment Video
Updated: May 30, 2025
06:19
A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
Published on: January 7, 2018
10.2K
Preterm Labor and Hypertensive Disorders in Adolescent Pregnancies With Diabetes Between 2006 and 2019
Estelle Everett1,2,3, Christina S Han4, Michael Richley5
1Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Pediatric Diabetes
|January 28, 2025
Summary
Adolescent pregnancies with diabetes, including type 1, type 2, and gestational diabetes, show significantly higher risks for preterm labor and hypertensive disorders. These findings highlight the need for targeted interventions to improve maternal and infant health outcomes in this population.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Public Health
Background:
- Adolescent pregnancies represent a vulnerable population with unique health considerations.
- The prevalence of diabetes among adolescents is increasing, raising concerns about pregnancy complications.
- Hypertensive disorders and preterm labor are significant risks in pregnancy, particularly in adolescent mothers.
Purpose of the Study:
- To evaluate the association between diabetes (type 1, type 2, and gestational) and the risk of preterm labor in adolescent pregnancies.
- To assess the risk of hypertensive disorders in adolescent pregnancies complicated by diabetes.
- To identify trends and disparities in these pregnancy complications among adolescents.
Main Methods:
- Utilized the national Kids' Inpatient Database (KID) from 2006-2019, analyzing over 1.8 million adolescent labor and delivery admissions.
- Employed International Classification of Diseases (ICD) codes to identify cases of diabetes and pregnancy complications.
- Applied weighted logistic regression to determine the adjusted odds ratios for hypertensive disorders and preterm labor in relation to diabetes status.
Main Results:
- Adolescents with any form of diabetes (T1D, T2D, GDM) had a significantly higher prevalence of both hypertensive disorders and preterm labor compared to those without diabetes (p <0.001).
- Adjusted models revealed increased odds of hypertensive disorders (OR 4.32 for T1D, 4.18 for T2D, 1.99 for GDM) and preterm labor (OR 4.53 for T1D, 3.35 for T2D, 1.18 for GDM) in diabetic adolescents.
- Disparities in outcomes were observed based on race/ethnicity, insurance status, and income levels.
Conclusions:
- Increasing diabetes in adolescents poses a significant risk for adverse pregnancy outcomes, including preterm labor and hypertensive disorders.
- Despite a decrease in adolescent pregnancies, rates of hypertensive disorders have risen, emphasizing the impact of diabetes.
- Urgent implementation of targeted interventions is crucial to mitigate risks and ensure healthier outcomes for pregnant adolescents with diabetes.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
01:20Pathophysiology of Diabetes
854
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
854
01:07Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
01:33Hormonal Regulation
32.9K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.9K
01:22Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
01:15Diabetes: Management and Pharmacotherapy
233
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
233