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Data acquisition from a multiplex, quadrupole mass spectrometer.

B L Graham, P R Buchanan, S J Withy

    Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Fur Medizinische Physik and the European Federation of Organisations for Medical Physics
    |February 1, 1985
    PubMed
    Summary
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    For respiratory mass spectrometers, discrete-time analysis is crucial for accurate gas concentration measurements. A simple time shift correction often suffices, potentially negating the need for complex continuous-time methods.

    Area of Science:

    • Physiology
    • Biomedical Engineering
    • Analytical Chemistry

    Background:

    • Respiratory mass spectrometry is vital for monitoring gas concentrations during breathing.
    • Existing correction methods address signal delay and rise time, but may not suit multiplex systems.
    • Multiplex mass spectrometers provide discrete gas samples, unlike continuous monitoring systems.

    Purpose of the Study:

    • To evaluate correction techniques for respiratory mass spectrometer outputs.
    • To compare continuous-time versus discrete-time analysis for multiplex systems.
    • To determine the efficacy of simple time shifts versus complex corrections.

    Main Methods:

    • Simulated multibreath gas washout analysis using 'square wave breathing'.
    • Comparison of discrete-time analysis with continuous-time analysis.

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  • Evaluation of a simple time shift correction method.
  • Assessment of a first-order response correction method.

    • Main Results:

    • Discrete-time analysis is more appropriate for multiplex mass spectrometers than continuous-time analysis.
    • A simple time shift correction significantly reduced measurement errors.
    • The simple time shift achieved error reduction comparable to a first-order response correction.
    • Complex corrections may be invalid or unnecessary in certain multiplex mass spectrometry scenarios.

    Conclusions:

    • Discrete-time analysis is essential for accurate gas concentration measurements with multiplex respiratory mass spectrometers.
    • A simple time shift is an effective and often sufficient correction method.
    • Complex correction techniques may not always be necessary or valid for multiplex systems, especially under specific conditions.