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Updated: May 5, 2026
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Detection and Isolation of Apoptotic Bodies to High Purity
Published on: August 12, 2018
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Apoptotic vesicles: emerging concepts and research progress in physiology and therapy
1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, South China Center of Craniofacial Stem Cell Research, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China.
Life Medicine
|January 28, 2025
Summary
Apoptotic vesicles (apoVs), generated during programmed cell death, are key regulators of tissue homeostasis. Research highlights their therapeutic potential in regenerative medicine for various diseases.
Area of Science:
- Cell Biology
- Regenerative Medicine
- Biochemistry
Background:
- Apoptosis, a critical form of programmed cell death, generates extracellular vesicles (EVs) known as apoptotic vesicles (apoVs).
- ApoVs possess unique biological and functional characteristics, acting as crucial regulators in diverse physiological processes.
- Dysregulation of apoVs is linked to age- and pathology-associated tissue alterations.
Purpose of the Study:
- To review the current scientific understanding of apoptotic vesicles (apoVs).
- To elucidate the mechanistic insights into apoV's role in organismal health and disease.
- To explore the potential of apoVs in cell-free regenerative therapeutics.
Main Methods:
- Literature review of studies on apoptotic vesicles (apoVs).
- Analysis of mechanistic insights into apoV production and function.
- Evaluation of therapeutic applications of apoVs, particularly from mesenchymal stem cells.
Main Results:
- ApoVs are critical regulators of tissue and organ homeostasis.
- Evidence suggests apoV dysregulation contributes to disease pathogenesis.
- ApoVs derived from mesenchymal stem cells show significant promise for regenerative therapies.
Conclusions:
- ApoVs are vital for maintaining physiological balance and their dysregulation contributes to disease.
- ApoVs offer novel cell-free strategies for EV-based regenerative therapeutics.
- Further research into apoVs can unlock their full translational potential in treating various conditions.
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