A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium

Area of Science:

• Gerontology
• Neuroscience
• Biomarker Discovery

Background:

• Global populations face significant aging challenges, increasing the prevalence of age-related diseases.
• Brain aging is a key factor in major neurological conditions like neurodegenerative diseases and stroke.
• Effective assessment of brain aging is crucial for developing interventions and treatments.

Purpose of the Study:

• To recommend validated biomarkers for assessing brain aging.
• To establish an expert consensus on brain aging assessment.
• To provide a foundation for research and improve global brain health in the elderly.

Main Methods:

• Consensus development by experts from the Aging Biomarker Consortium (ABC).
• Integration of the latest research findings and practical clinical experience.
• Identification and recommendation of specific brain aging biomarkers.

Main Results:

• A consensus on recommended brain aging biomarkers has been established.
• A framework for assessing the degree of brain aging is proposed.
• The recommendations aim to support targeted research and clinical applications.

Conclusions:

• The expert consensus provides a basis for evaluating brain aging.
• This initiative is vital for advancing strategies to combat age-related brain diseases.
• The ultimate goal is to enhance the brain health of aging populations worldwide.