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Updated: May 30, 2025
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Allostatic Load and Oxidative Stress Markers in Women With Early- and Late-Onset Preeclampsia
Araceli Montoya-Estrada1, María Valeria García-Cerda1, Alberto Martin Guzmán-Grenfell2
1Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology Isidro Espinosa de los Reyes, Mexico City, MEX.
Background:
Allostatic load and oxidative stress (OS) markers differ in women with and without preeclampsia. However, there is no difference in allostatic load and OS markers between late-onset preeclampsia (L-OP) and early-onset preeclampsia (E-OP). This study aimed to compare the concentrations of allostatic load and OS markers in pregnant women with L-OP and E-OP.
Methods:
This was a comparative cross-sectional study. Women with single pregnancy and a diagnosis of preeclampsia were included. Women with multiple pregnancies and/or chronic hypertension were excluded. Group 1 included women with E-OP (n=16), Group 2 included women with L-OP (n=45), and Group 3 included women without preeclampsia (n=40).
Results:
No statistical differences were found in maternal age, body mass index, or number of gestations. Arginase levels were higher in Group 1 compared to Group 2 (p = 0.04) and Group 1 compared to Group 3 (p = 0.01). Total antioxidative capacity was higher in Group 1 compared to Group 2 (p = 0.03) and Group 1 compared to Group 3 (p = 0.001). Malondialdehyde levels were higher in Group 1 compared to Group 2 (p = 0.001) and Group 1 compared to Group 3 (p = 0.001). Total sulfhydryl compounds were lower in Group 1 compared to Group 2 (p = 0.01) and Group 1 compared to Group 3 (p = 0.001). No differences were observed between study groups in allostatic load markers.
Conclusions:
Higher levels of OS markers were found in women with E-OP compared to women with L-OP and controls.
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