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Pan-cancer Analysis Of The Prognostic And Immunotherapeutic Value Of Pdgfb.

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Pan-cancer Analysis Of The Prognostic And Immunotherapeutic Value Of Pdgfb.

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Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB.

Yuwei Bai^1,2, Xiaoyun Wang^1,2, Bei Wang^1,2

¹Institute of Integration of Traditional Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, People's Republic of China.

Immunotargets and Therapy

|January 28, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Platelet-derived growth factor-B (PDGFB) shows complex roles in various cancers, acting as a prognostic marker and potential immunotherapy target. Its expression impacts tumor progression and immune cell infiltration, offering new clinical insights.

Keywords:

PDGFB biomarker immune cell infiltration pan-cancer prognosis

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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

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Area of Science:

Oncology
Molecular Biology
Immunology

Background:

Cancer remains a global health challenge, necessitating the identification of novel therapeutic targets.
Platelet-derived growth factor-B (PDGFB) is implicated in tumor angiogenesis and metastasis, yet its precise role requires further elucidation.

Purpose of the Study:

To comprehensively analyze the expression, prognostic value, stemness association, and immunological impact of PDGFB across diverse cancer types.
To validate findings using clinical samples and immunohistochemistry.

Main Methods:

Utilized multi-database analysis to investigate PDGFB expression, clinical outcome correlations, tumor stemness links, and immune cell infiltration.
Employed immunohistochemistry for validation in clinical samples.

Main Results:

PDGFB expression varied across cancers, generally correlating with poor prognosis, but showing exceptions like good prognosis in renal clear cell carcinoma.
PDGFB associated with tumor stemness and increased lymphocyte infiltration, correlating positively with CD8 and PDL1 in lower grade glioma.
Demonstrated PDGFB's complex role in influencing cancer malignancy and immune responses.

Conclusions:

PDGFB presents potential as a prognostic biomarker and a targetable pathway for cancer immunotherapy.
Findings highlight PDGFB's significant clinical implications in oncology and cancer immunology.