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Related Experiment Video

Updated: May 30, 2025

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
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Preoperative serum total bilirubin-albumin ratio as a prognostic indicator in patients with hepatitis-related

Yi-Fan Chen1,2, Yu-Xin Lin1,3, Miao-Miao Chi1,4

  • 1Department of Hepatobiliary Surgery, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China.

World Journal of Gastrointestinal Surgery
|January 28, 2025
PubMed
Summary
This summary is machine-generated.

The bilirubin-albumin (B/A) ratio effectively predicts long-term survival in hepatitis cirrhosis patients after splenectomy. A higher B/A ratio indicates a poorer prognosis, aiding clinical decision-making.

Keywords:
Hepatitis-related cirrhosisPrognosisSerum total bilirubin-albumin ratioSplenectomySurvival

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Area of Science:

  • Hepatology
  • Surgical Oncology
  • Clinical Prognostics

Background:

  • Splenectomy is a common intervention for portal hypertension in hepatitis cirrhosis.
  • Existing prognostic indicators for long-term survival after splenectomy have limitations.

Purpose of the Study:

  • To evaluate the preoperative total bilirubin-albumin (B/A) ratio as a prognostic marker.
  • To assess its utility in predicting overall survival in hepatitis cirrhosis patients undergoing splenectomy.

Main Methods:

  • Retrospective analysis of 257 hepatitis cirrhosis patients.
  • Statistical analyses including t-test, Wilcoxon test, chi-squared test, and Fisher's exact test.
  • Receiver operating characteristic (ROC) curve analysis for 10-year overall survival.

Main Results:

  • The total serum B/A ratio was an independent risk factor for overall survival (P=0.037).
  • An optimal B/A ratio cut-off of 0.87 was identified.
  • Patients with a high B/A ratio had significantly lower 10-year overall survival (P<0.001).

Conclusions:

  • The B/A ratio is an effective prognostic indicator for hepatitis B virus-related cirrhosis patients post-splenectomy.
  • A higher B/A ratio correlates with a poorer prognosis, informing clinical management.