A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement

Area of Science:

• Cardiology
• Gerontology
• Biomarker Research

Background:

• Cardiac aging is a significant risk factor for cardiovascular diseases in the elderly.
• Preventive and management strategies for age-related cardiovascular conditions are crucial for well-being.
• The Aging Biomarker Consortium (ABC) of China addresses this challenge through expert consensus.

Purpose of the Study:

• To provide a comprehensive assessment of cardiac aging biomarkers.
• To establish a standardized methodology for characterizing these biomarkers.
• To offer a dependable reference for clinical applications and future research.

Main Methods:

• Literature review and clinical expertise synthesis.
• Standardized methodology for biomarker characterization across functional, structural, and humoral dimensions.
• Inclusion of systemic and heart-specific markers.

Main Results:

• Defined functional biomarkers reflecting cardiac performance and metabolism.
• Identified structural imaging markers for cardiac remodeling and fat deposition.
• Highlighted humoral markers including hormones, cytokines, and metabolites.

Conclusions:

• The consensus establishes a robust foundation for assessing cardiac aging.
• This framework aims to enhance cardiovascular health and well-being in the elderly.
• It serves as a vital reference for clinical practice and scientific advancement.