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Updated: May 30, 2025
Detection of Protein Aggregation using Fluorescence Correlation Spectroscopy
Published on: April 25, 2021
A triphenylamine-based aggregation-induced emission active fluorescent probe for fluorescent ink, fingerprint powder,
Keli Zhong1, Shuang Liu1, Yangyang Li1
1College of Chemistry and Materials Engineering; Institute of Ocean, Bohai University, Jinzhou, China.
Background:
Multifunctional fluorescent probes have attracted much attention due to their wide range of applications and high utilization. In this study, a multifunctional fluorescent probe (E)-3-(4-(7-(4-(diphenylamino)phenyl)benzo[c] [1,2,5]thiadiazol-4-yl)phenyl)acrylic acid (TBAC) based on triphenylamine was designed and synthesized.
Results:
The TBAC probe provided excellent aggregation-induced emission (AIE) performance and could be used as a fluorescent ink for printing. It was also prepared successfully for application as a fingerprint powder, facilitating the visual detection of invisible fingerprints on surfaces such as glass, plastic, tinfoil, metal, aluminum, and resin. The probe exhibited a clear fluorescence response to 12 volatile amines via an AIE-based 'on-off' mechanism in an EtOH/H2O (4/6, v/v) solution. The TBAC/bromocresol green (BCG) indicator label also enabled non-destructive and rapid assessment of salmon freshness through dual-channel colorimetric and fluorescence responses.
Conclusion:
The versatility of TBAC makes it a promising material for various applications, including fluorescent materials, criminal detection, and food safety. This study provides a new basis for the multifunctional application of fluorescent probes. © 2025 Society of Chemical Industry.
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