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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Development of optical microneedle-lens array for photodynamic therapy.

Jongho Park¹, Jingzong Zhang², Beomjoon Kim³

¹Institute of Industrial Science, The University of Tokyo, Meguro-Ku, 153-8505, Tokyo, Japan.

Biomedical Microdevices

|January 28, 2025

Summary

Optical microneedle-lens arrays (OMLA) improve photodynamic therapy (PDT) for skin cancer. This novel device enhances light delivery and photosensitizer release, increasing treatment efficiency and safety.

Keywords:

Microneedle array patch Non-melanoma skin cancer Optical microneedle–lens array Photodynamic therapy TMPyP

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Area of Science:

Biomedical Engineering
Photomedicine
Dermatology

Background:

Photodynamic therapy (PDT) uses photosensitizers (PS) and light to treat skin conditions like cancer.
Current PDT faces challenges with limited light penetration and potential off-target damage.
Existing methods require precise light delivery to overcome scattering and absorption in skin layers.

Purpose of the Study:

To develop an optical microneedle-lens array (OMLA) for enhanced PDT efficiency and safety.
To optimize light transmission and photosensitizer delivery for skin cancer treatment.
To address limitations of conventional PDT in clinical applications.

Main Methods:

Designed and fabricated a novel OMLA with controlled dimensions for optimized light transmission.
Coated photosensitizer (PS) uniformly onto the OMLA tips using a dip-coating method.
Confirmed PS release from OMLA and subsequent radical oxygen generation upon light irradiation.

Main Results:

The OMLA demonstrated effective light transmission for PDT activation.
Uniform PS coating and controlled release from the OMLA were achieved.
Successful generation of radical oxygen confirmed the therapeutic potential of the OMLA system.

Conclusions:

The OMLA system offers a promising new platform for targeted PDT in skin cancer treatment.
This approach enhances light delivery and PS localization, improving therapeutic outcomes.
OMLA technology has the potential to overcome key limitations of conventional PDT.