Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

4.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study of phosphorylated ribosomal protein S6 (pS6) in the clinical outcomes of patients undergoing hepatectomy for metastatic colorectal cancer.

World journal of surgical oncology·2026
Same author

The pterocarpan (+)-PTC modulates cytoskeletal proteins and induces apoptosis in metastatic castration-resistant prostate cancer: a proteomic perspective.

Frontiers in pharmacology·2026
Same author

The overlooked role of genetic ancestry in global breast cancer burden estimates.

Medical oncology (Northwood, London, England)·2026
Same author

Carney complex with PRKAR1A variant and breast/fibrolamellar carcinomas.

Human genome variation·2026
Same author

Corticoids Reduce Incidence of Oral Mucositis during Antineoplastic Treatment? A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Clinical Trials.

Asian Pacific journal of cancer prevention : APJCP·2026
Same author

High-performance countercurrent chromatography isolation of flavonoids from a cytotoxic extract of Andira parviflora (Ducke) waste wood from the Amazon region.

Journal of chromatography. A·2026

Related Experiment Video

Updated: May 5, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.5K

The p16 Immunostaining Predicts the Risk of Recurrence in Prostate Cancer.

Sara Lourrane Carneiro De Andrade Cavalcante1, Paulo Goberlânio De Barros Silva1, Carlos Gustavo Hirth1

  • 1Postgraduate Program in Oncology, Haroldo Juaçaba Hospital, Ceará Cancer Institute (ICC), Brazil.

Asian Pacific Journal of Cancer Prevention : APJCP
|January 28, 2025
PubMed
Summary
This summary is machine-generated.

p16 immunostaining predicts biochemical recurrence in prostate cancer. Combined with Gleason Score and surgical margins, p16 expression aids in assessing recurrence risk for pT2-pT3 tumors.

Keywords:
Prostate neoplasmsRecurrence Timehuman papillomavirus

More Related Videos

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.1K
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
10:26

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

27.3K

Related Experiment Videos

Last Updated: May 5, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.5K
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.1K
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
10:26

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

27.3K

Area of Science:

  • Oncology
  • Pathology
  • Biochemistry

Background:

  • Prostate cancer staging (pT2-pT3) is crucial for treatment decisions.
  • Biochemical recurrence is a key indicator of treatment efficacy.
  • Understanding predictors of recurrence is vital for patient management.

Purpose of the Study:

  • To evaluate the impact of p16 immunohistochemical expression on biochemical recurrence rates.
  • To correlate p16 expression with established prognostic factors in prostate cancer.

Main Methods:

  • Analysis of 488 radical prostatectomy specimens (pT2-pT3 prostate adenocarcinoma).
  • Immunohistochemistry performed for p16 expression.
  • Statistical analysis included chi-square, Fisher's exact test, and logistic regression.

Main Results:

  • Over 94% of cases showed p16 positivity.
  • Biochemical recurrence was associated with high PSA, positive margins, pT3 stage, nodal involvement, higher Gleason score, and lower p16 positivity/histoscore.
  • Multivariate analysis identified Gleason score > 3+4, positive surgical margins, and p16 histoscore ≤3 as independent predictors of recurrence.

Conclusions:

  • p16 immunostaining is a significant predictor of biochemical recurrence in pT2-pT3 prostate cancer.
  • p16 expression, alongside Gleason Score and surgical margins, improves risk stratification.
  • These findings can aid in refining treatment strategies and patient follow-up.