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Updated: May 30, 2025

Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug
Published on: December 14, 2021
ABT, Elacridar and Bile-Duct Cannulated Rats: Tools to Understand Pharmacokinetics
1NRG Therapeutics, Stevenage, United Kingdom.
Abstract:
Optimizing pharmacokinetics is an integral part of drug design, albeit a lesser understood one from the medicinal chemist's perspective. Over the years, molecular tools and experimental strategies have been developed to better understand the fate of compounds. Among these, the use of aminobenzotriazole (ABT), elacridar and bile-duct cannulated rats have been instrumental in gaining valuable PK insights, with a direct impact on drug design.
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