Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

1.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.2K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

944
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
944
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

957
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
957
Disorders of Leukocytes01:27

Disorders of Leukocytes

843
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
843
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

1.3K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophages de<i>liver</i> growth.

Science signaling·2025
Same author

Making sense of gastric cancer.

Science signaling·2025
Same author

In Science Journals.

Science (New York, N.Y.)·2025
Same author

Healing limited.

Science signaling·2024
Same author

Neurons go antiviral.

Science signaling·2024
Same author

Plaque to the future.

Science signaling·2024

Related Experiment Video

Updated: May 30, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.3K

Alarmin' lymphoid developments.

Amy E Baek1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|January 28, 2025
PubMed
Summary

The alarmin cytokine Interleukin-33 (IL-33) promotes the development of immune cell clusters in non-responsive tumors. This finding offers new insights into overcoming tumor immune evasion.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Tumor microenvironments are often "cold," lacking immune cell infiltration.
  • Immune evasion is a major challenge in cancer therapy.
  • Interleukin-33 (IL-33) is an alarmin cytokine with known immune-modulatory functions.

Purpose of the Study:

  • To investigate the role of IL-33 in shaping the tumor immune microenvironment.
  • To determine if IL-33 can convert "cold" tumors into immunologically active sites.

Main Methods:

  • In vivo tumor models were utilized.
  • Analysis of immune cell populations within tumors was performed.
  • The effects of IL-33 administration on tumor growth and immune infiltration were assessed.

More Related Videos

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
07:40

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

13.1K
Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

6.0K

Related Experiment Videos

Last Updated: May 30, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.3K
Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
07:40

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

13.1K
Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
09:10

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin

Published on: December 16, 2013

6.0K

Main Results:

  • IL-33 administration led to the formation of "immune hubs" within tumors.
  • These immune hubs were characterized by increased infiltration of specific immune cell types.
  • The presence of IL-33 correlated with enhanced anti-tumor immune responses.

Conclusions:

  • The alarmin cytokine IL-33 actively promotes the formation of immune aggregates in "cold" tumors.
  • IL-33 represents a potential therapeutic target for enhancing anti-tumor immunity.