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Pyoderma Gangrenosum Improved with Dapsone and Prednisone: A Case Report
Arbie Sofia P Merilleno1, Charlene Marie Ang-Tiu
1Arbie Sofia P. Merilleno, MD, DPDS, is an Inflammatory Disease Fellow, University of Toronto, Ontario, Canada; Clinical Fellow, Women's College Hospital, Ontario; and Research Fellow, Women's College Research Institute, Ontario. Charlene Marie Ang-Tiu, MD, FPDS, is Medical Specialist, Rizal Medical Center, Pasig City, Philippines. The authors have disclosed no financial relationships related to this article. Submitted November 11, 2023; accepted in revised form April 2, 2024.
Pyoderma gangrenosum, a rare ulcerative condition, can be effectively treated with a combination of prednisone and dapsone. This therapeutic approach led to complete resolution in a patient with long-standing, nonhealing ulcers.
Area of Science:
- Dermatology
- Immunology
Background:
- Pyoderma gangrenosum (PG) is a rare, chronic ulcerative condition.
- Diagnosis and management are challenging due to rarity and varied presentations.
- Delayed treatment can lead to significant morbidity.
Purpose of the Study:
- To report a case of pyoderma gangrenosum successfully treated with a combination therapy.
- To highlight an effective treatment strategy for recalcitrant cases.
Main Methods:
- A case report of a 36-year-old male patient with nonhealing ulcers.
- Treatment involved oral corticosteroids (prednisone) and dapsone.
- Response to therapy was monitored over six months.
Main Results:
- The patient presented with long-standing ulcers unresponsive to antibiotics and debridement.
- Combination therapy with prednisone and dapsone resulted in complete resolution of lesions.
- The treatment was well-tolerated over a 6-month period.
Conclusions:
- Combined prednisone and dapsone therapy can be a valuable option for pyoderma gangrenosum.
- This treatment approach may be particularly beneficial in resource-limited settings.
- Early diagnosis and appropriate management are crucial for favorable outcomes in PG.
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