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Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion.
Irina Filz von Reiterdank1,2,3, Raphaela Bento1,2,4, Insoo Hyun5
1Center for Engineering in Medicine and Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA;
Annual Review of Biomedical Engineering
|January 28, 2025
Summary
Gene therapy combined with ex vivo machine perfusion (EVMP) enables organ genetic engineering for transplantation. This approach promises enhanced graft survival and fewer complications, paving the way for future therapeutic applications.
Area of Science:
- Regenerative Medicine
- Transplantation Biology
- Genetic Engineering
Background:
- Gene therapy is advancing, offering clinical benefits.
- Genetic engineering of organs for transplantation is an emerging possibility.
- Ex vivo machine perfusion (EVMP) is a breakthrough technology enabling organ access for manipulation.
Purpose of the Study:
- To review current methodologies for delivering genetic vectors to transplantable organs.
- To highlight the enabling role of EVMP in organ genetic engineering.
- To discuss applications, challenges, and future directions for this technology.
Main Methods:
- In-depth discussion of genetic vector delivery techniques.
- Focus on the application of EVMP for organ manipulation.
- Organ-specific analysis of vector and treatment options.
Main Results:
- EVMP facilitates genetic manipulation of functioning organs prior to transplantation.
- This combined approach has the potential to improve genetic engineering efficiency.
- Potential benefits include enhanced graft survival and reduced post-transplant complications.
Conclusions:
- The convergence of gene therapy and EVMP offers a promising future for organ transplantation.
- Ethical and regulatory considerations are crucial for societal benefit.
- A roadmap for research and clinical translation requires scientific advancement and anticipatory governance.
