Progression of photoresin-based microneedles: From established drug delivery to emerging biosensing technologies

Microneedles have emerged as a highly promising technology for advancing chemical biosensing and drug delivery applications, offering a minimally invasive, efficient, and versatile approach to healthcare innovation. This review provides a comprehensive analysis of photoresin-based microneedles, with a particular focus on SU-8 photoresin due to its favorable mechanical properties, biocompatibility, and ease of fabrication. Advanced techniques for surface modification are discussed to enhance the functionality of microneedles, enabling their application in precise biochemical diagnostics and effective drug therapy. Additionally, a concise overview of the two-photon polymerization technology is presented, emphasizing its remarkable potential in the production of microneedle arrays. By examining the various types of resins employed in the production of microneedles and their integration with nanostructures, this review offers valuable insights into the development and optimization of microneedle-based systems for diverse healthcare purposes.