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[Isolated elevation of serum alkaline phosphatase].
Deutsche Medizinische Wochenschrift (1946)
|April 26, 1985
Summary
Transient or persistent high serum alkaline phosphatase (AP) levels in children and adults, without signs of liver or bone disease, often involve isolated enzyme elevations. This finding is benign and can prevent unnecessary medical investigations.
Area of Science:
- Biochemistry
- Clinical Chemistry
- Enzymology
Context:
- Elevated serum alkaline phosphatase (AP) levels can indicate underlying liver or bone disease.
- Distinguishing the source of elevated AP is crucial for accurate diagnosis.
- Idiopathic or benign hyperphosphatasaemia requires differentiation from pathological conditions.
Purpose:
- To analyze serum alkaline phosphatase (AP) isoenzymes in individuals with unexplained hyperphosphatasaemia.
- To determine the isoenzyme profiles associated with transient versus persistent elevations.
- To assess the clinical significance of isolated AP isoenzyme elevations.
Summary:
- Serum AP isoenzymes were measured in 17 children and 3 adults with elevated AP levels but no evidence of hepatobiliary or bone disease.
- In transient hyperphosphatasaemia, both liver and bone AP were elevated in most children.
- Persistent hyperphosphatasaemia showed elevations in only one AP isoenzyme (liver or bone).
Impact:
- Identifies isolated hyperphosphatasaemia as a benign anomaly.
- Highlights the importance of AP isoenzyme analysis in avoiding unnecessary investigations.
- Provides a basis for reassuring patients and clinicians about benign findings.