Related Experiment Video

Updated: Jul 29, 2026

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
05:58

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

[Differential therapy with calcium antagonists. Hemodynamic studies using nifedipine, verapamil and diltiazem]

H U Lehmann, H Hochrein

    Deutsche Medizinische Wochenschrift (1946)
    |April 26, 1985
    PubMed

    Insights

    Calcium channel blockers like nifedipine, verapamil, and diltiazem lower blood pressure in coronary heart disease patients. However, they affect heart rate and stroke volume differently, suggesting varied therapeutic uses.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Coronary heart disease (CHD) management often involves calcium channel blockers.
    • Understanding the differential hemodynamic effects of these drugs is crucial for optimizing patient care.

    Purpose of the Study:

    • To compare the hemodynamic effects of nifedipine, verapamil, and diltiazem in patients with CHD.
    • To evaluate the impact of these calcium antagonists on systemic arterial pressure, left-ventricular stroke work, heart rate, and stroke volume.

    Main Methods:

    • An open randomized parallel study involving 44 patients with CHD.
    • Hemodynamic parameters were measured at rest and during exercise, before and after single doses of nifedipine (20 mg), verapamil (160 mg), and diltiazem (120 mg).

    Main Results:

    • All three drugs significantly reduced systemic arterial pressure (10-14%) and left-ventricular stroke work (10-20%).
    • Nifedipine increased heart rate, while verapamil and diltiazem decreased it.
    • Verapamil reduced stroke-volume index, whereas nifedipine and diltiazem did not alter it.

    Conclusions:

    • Nifedipine, verapamil, and diltiazem exhibit distinct hemodynamic profiles.
    • These differences suggest that the choice of calcium antagonist may be tailored to individual patient needs in CHD management.

    More Related Videos

    Preparation of Human Myocardial Tissue for Long-Term Cultivation10:58

    Preparation of Human Myocardial Tissue for Long-Term Cultivation

    Published on: June 2, 2022

    Real-time Evaluation of Absolute, Cytosolic, Free Ca2+ and Corresponding Contractility in Isolated, Pressurized Lymph Vessels08:46

    Real-time Evaluation of Absolute, Cytosolic, Free Ca2+ and Corresponding Contractility in Isolated, Pressurized Lymph Vessels

    Published on: March 22, 2024

    Related Concept Videos

    Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

    Antihypertensive Drugs: Action of Calcium Channel Blockers

    Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
    Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers01:20

    Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers

    Class IV antiarrhythmic drugs, such as verapamil and diltiazem, block calcium channels. They primarily affect the heart, slowing the conduction in calcium-dependent tissues like the SA and AV nodes. These drugs manage reentrant supraventricular tachycardia (SVT) and reduce ventricular rate in atrial flutter/fibrillation.
    Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
    Antianginal Drugs: Calcium Channel Blockers and Ranolazine01:25

    Antianginal Drugs: Calcium Channel Blockers and Ranolazine

    Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
    CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
    Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

    Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

    Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
    TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
    Coronary Artery Disease V: Interprofessional Care01:27

    Coronary Artery Disease V: Interprofessional Care

    Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
    Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

    Hypertension IV: Drug Therapy and Lifestyle Modifications

    Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...