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Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain

Silas A Buck1,2, Samuel J Mabry2, Jill R Glausier2

  • 1Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.

Molecular Psychiatry
|January 28, 2025
PubMed
Summary

Healthy aging shows decreased dopamine neuron gene expression in mice and humans, but not cell loss. Protein levels remain stable, suggesting resilience mechanisms against neurodegeneration.

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