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Related Concept Videos

Depression: Overview01:18

Depression: Overview

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Depressive Disorders: MDD and Dysthymia01:27

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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Depressive Disorders: Etiology01:27

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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G-protein Coupled Receptors01:21

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Antidepressant Drugs: Overview01:25

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Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
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Related Experiment Video

Updated: May 30, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
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[Interplay between depression and sexuality].

Jörg Signerski-Krieger1,2, Lara Schleifenbaum3

  • 1Klinik für Psychiatrie und Psychotherapie, Asklepios Fachklinikum Tiefenbrunn, Deutschland37124, Rosdorf, Deutschland. j.signerski@asklepios.com.

Der Nervenarzt
|January 28, 2025
PubMed
Summary

Depression often causes sexual dysfunction, and some antidepressants worsen this. Open discussion and treatment adjustments are key for managing these interconnected issues in patients.

Keywords:
AntidepressantsPsychotherapySexual dysfunctionsSexual partnersTherapy

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Area of Science:

  • Psychiatry and Psychology
  • Sexual Medicine

Context:

  • Sexual dysfunction is a common comorbidity with depression.
  • Complex interactions exist between psychological, sexual, and relationship health in depressed individuals.

Purpose:

  • Determine the prevalence of sexual functional disorders in depressed patients.
  • Assess the impact of antidepressant medications on sexual function.
  • Develop evidence-based treatment recommendations.

Summary:

  • Depression and sexual dysfunction are highly interrelated, necessitating the inclusion of interpersonal dynamics in therapy.
  • Serotonergic antidepressants can elevate sexual dysfunction risk significantly (up to 27-fold).
  • Treatment options include dose reduction, medication switching (e.g., to bupropion), or adjunctive therapies, alongside couples counseling.

Impact:

  • Highlights the critical need for therapists to proactively address sexual health concerns with patients.
  • Emphasizes patient education regarding potential sexual side effects of antidepressants before treatment initiation.
  • Underscores the importance of considering relationship dynamics in the comprehensive management of depression.