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Investigating orbital foreign device-associated malignancies: a scoping review
Jeong Hyun Ha1,2,3, Jagmeet S Arora4, Jamasb J Sayadi5
1Interdisciplinary Program of Medical Informatics, Seoul National University College of Medicine, Seoul, South Korea. hjeong907@gmail.com.
BMC Cancer
|January 28, 2025
Summary
Malignancies can occur after ophthalmic surgeries involving foreign devices like scleral shells and orbital implants. Further research is needed to confirm the link between these devices and cancer development.
Area of Science:
- Ophthalmology
- Oncology
- Medical Devices
Background:
- Prosthesis-associated malignancies are acknowledged but under-recognized in ophthalmology.
- Ophthalmologic surgeries frequently involve foreign devices, increasing potential risks.
- Limited awareness exists among surgeons and patients regarding these risks.
Purpose of the Study:
- To conduct a scoping review of malignancies following ophthalmologic surgeries involving foreign devices.
- To address the knowledge gap regarding cancer risks associated with ophthalmic implants.
- To identify types of devices and associated malignancies.
Main Methods:
- Systematic literature review following PRISMA guidelines.
- Searched PubMed and Embase for studies on cancer and ophthalmic prostheses/implants.
- Rigorous selection and analysis of relevant ophthalmology studies.
Main Results:
- Analyzed 30 studies, identifying 41 cases of malignancies post-orbital foreign device interventions.
- Associated devices included scleral shells, orbital implants, scleral buckles, encircling bands, and gold plates.
- Ocular surface squamous neoplasm was most frequent (29 cases); other cancers included sarcomas, lymphomas, and carcinomas. Median time to tumor development was 40 years.
Conclusions:
- A spectrum of malignancies is associated with orbital foreign device procedures.
- Potential causal relationships between specific orbital devices and malignancies are suggested.
- Further epidemiologic studies and scientific experiments are required to confirm causality.
