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Related Concept Videos

Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Alternative Methods01:17

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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...

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Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
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Optical method for dissolution/diffusion process multiparameters simultaneous measurement based on liquid-core

Rui Zeng, Zhiwei Li, Danyang Wang

    Optics Express
    |January 29, 2025
    PubMed
    Summary
    This summary is machine-generated.

    This study presents a novel optical method to simultaneously measure dissolution rate, dissolution rate constant, and diffusion coefficient for solids in liquids. This technique offers a faster, more intuitive approach for critical parameter measurement in various industries.

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    Area of Science:

    • Physical Chemistry
    • Materials Science
    • Chemical Engineering

    Background:

    • Solid dissolution and diffusion in liquids are fundamental processes with critical parameters like dissolution rate (dC/dt), dissolution rate constant (K), and diffusion coefficient (D).
    • Current methods for measuring these parameters are often time-consuming, indirect, and cannot determine them simultaneously.
    • Accurate measurement of these parameters is vital for applications in biopharmaceuticals, materials science, and agriculture.

    Purpose of the Study:

    • To develop and validate a novel optical method for the simultaneous measurement of dissolution rate, dissolution rate constant, and diffusion coefficient.
    • To apply this method to potassium dihydrogen phosphate (KDP) in powder, solid, and crystal forms dissolving in water.
    • To provide a more intuitive and efficient alternative to existing measurement techniques.

    Main Methods:

    • Utilized a compound liquid-core cylindrical lens (SLCL-Doublet) with real-time optical image feature extraction.
    • Correlated dissolution/diffusion image width with solution concentration to establish dynamic spatiotemporal concentration distribution.
    • Applied Fick's second law for diffusion coefficient (D) calculation and the Noyes-Whitney equation for dissolution rate (dC/dt) and rate constant (K) calculation.

    Main Results:

    • Successfully measured multiple dissolution and diffusion parameters simultaneously for KDP under different states.
    • Calculated diffusion coefficient (D), dissolution rate (dC/dt), and dissolution rate constant (K) using the developed optical method.
    • Validated measurement accuracy by determining solid-liquid contact surface area via the Nernst-Brunner equation.

    Conclusions:

    • The developed optical method enables simultaneous, real-time measurement of key dissolution and diffusion parameters.
    • This technique offers a significant improvement in efficiency and intuitiveness compared to traditional methods.
    • The method has broad applicability for expanding fundamental data in chemical and pharmaceutical industries.