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Salivary Inflammatory Mediator Profiles in Periodontal and Peri-Implant Health and Disease: A Cross-Sectional Study
Carl Titusson1, Leif Jansson2,3, Carolina Modin2,3
1Department of Dental Medicine, Division of Pediatric Dentistry, Karolinska Institutet, Huddinge, Sweden.
Objective:
This cross-sectional study aimed to investigate the salivary profile of inflammatory mediators in individuals with periodontal and peri-implant disease as compared to individuals with periodontal and peri-implant health.
Materials And Methods:
Saliva samples were collected from 155 participants (mean age 63.3 ± 11.4 years), comprising individuals with periodontal and peri-implant health (N = 41), gingivitis and/or mucositis (N = 18), and periodontitis and/or peri-implantitis (N = 96). Samples were analyzed using multiplex-immunoassay panel consisting of inflammatory mediators in the tumor necrosis factor (TNF), interferon (IFN), interleukin (IL) superfamily, and matrix metalloproteinases.
Results:
The levels of B-cell activating factor (BAFF), sIL-6Rβ, IFN-β, and sIL-6Rα, sTNFR1, and Pentraxin-3 were significantly higher in patients with periodontitis and/or peri-implantitis compared to healthy subjects. Furthermore, among the investigated inflammatory mediators, Pentraxin-3 exhibited the highest diagnostic potential (AUC = 0.74) for distinguishing between subjects with periodontitis and/or peri-implantitis and healthy individuals.
Conclusions:
Our findings demonstrated elevated salivary levels of BAFF, sIL-6Rβ, IFN-β, sIL-6Rα, sTNF-R1, and Pentraxin-3 in individuals with periodontitis and/or peri-implantitis in comparison to periodontal and peri-implant healthy controls.
