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Published on: December 8, 2023
Arechuines A-D, arecoline alkaloids from the peels of Areca catechu L
Biao Sun1, Yuanning Wu1, Jianzhan Yang2
1Guangdong Provincial Engineering Research Center for Modernization of TCM, NMPA Key Laboratory for Quality Evaluation of TCM, College of Pharmacy, Jinan University, Guangzhou, China.
Abstract:
Four novel arecoline alkaloid atropisomers, arechuines A-D (1 - 4), were obtained from the peels of Areca catechu L. Their structures were elucidated by UV, IR, MS and NMR spectra. The absolute configurations of (+)/(-)-4 were determined by comparing the experimental and calculated ECD spectra. Compounds 1 - 4 were evaluated for their neuroprotective effects in glutamate-induced HT22 cell and 3 revealed potent neuroprotective effects at 10 μM. These are the first reported arecoline alkaloid atropisomers isolated from A. catechu.
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