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Related Experiment Video

Updated: May 30, 2025

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics
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Fluoropolymer-Single Crystal Nanocomposite Based Transducer Fabrication for Bio-Imaging.

Nagendra Singh1, S K Biswas1

  • 1Department of Physical Sciences, Indian Institute of Science Education and Research Mohali, Knowledge City, Sector 81, SAS Nagar, Manauli, 140306, India.

Advanced Healthcare Materials
|January 29, 2025
PubMed
Summary

This study developed novel fluoropolymer and barium titanate composite transducers for high-resolution ultrasound and photoacoustic imaging. These advanced sensors offer a promising alternative for non-destructive testing and in-vivo imaging applications.

Keywords:
RBC and blood vessel imagingcomposite polymerin‐vivo non‐invasive imagingphotoacoustic microscopyultrasound transducer

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanoscience

Background:

  • Lead-based piezoelectric materials face challenges in developing practical sensors for photoacoustic and ultrasound applications.
  • Fluoropolymers offer potential as alternatives but require enhancement for high-performance sensing.
  • Need for advanced transducers for high-resolution in-vivo imaging and non-destructive testing.

Purpose of the Study:

  • To fabricate high-frequency, wide-bandwidth transducers using a novel fluoropolymer and barium titanate composite.
  • To develop a bio-compatible nanocomposite sensor film for improved polarization, crystallinity, and charge generation.
  • To demonstrate the efficacy of these transducers for in-vivo photoacoustic and ultrasound imaging.

Main Methods:

  • Synthesis of a Polyvinylidene fluoride trifluoroethylene (PVDF-TrFE)/Barium titanate (BaTiO3) nanocomposite film via drop-dry method with electro-poling.
  • Optimization of the PVDF-TrFE/BaTiO3 ratio using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and electrometer measurements.
  • Characterization of the sensing film's surface morphology and thermal stability using Scanning Electron Microscopy (SEM) and Thermogravimetric Analysis (TGA).

Main Results:

  • Fabrication of transducers with central frequencies ranging from 17 to 42MHz.
  • Successful testing in pulse-echo mode and for receiving photoacoustic signals from hemoglobin and eumelanin.
  • Demonstrated high-resolution in-vivo ultrasound and photoacoustic imaging, comparable to commercial devices.

Conclusions:

  • The novel fluoropolymer/cubic single-crystal BaTiO3 nanocomposite enables the fabrication of high-performance ultrasound and photoacoustic transducers.
  • This represents the first reported fabrication of such transducers using this specific nanocomposite material.
  • The developed transducers show significant potential for advanced biomedical imaging and non-destructive testing applications.