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Updated: May 30, 2025
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
328
Increased sodium consumption is associated with psoriasis: A population-based cohort study.
Aheli Chattopadhyay1, Morgan Ye1, Brenda Chiang1
1Department of Dermatology, University of California San Francisco, San Francisco, California, USA.
Summary
Increased dietary sodium intake is linked to a higher likelihood of developing psoriasis. This association was observed in large population studies, suggesting sodium reduction may benefit psoriasis patients.
Area of Science:
- Dermatology
- Nutrition Science
- Epidemiology
Background:
- Sodium accumulation in skin may exacerbate autoimmune conditions like psoriasis.
- Previous research indicated elevated skin sodium in severe psoriasis, but population-level dietary sodium intake and psoriasis association remained uninvestigated.
Purpose of the Study:
- To determine if dietary sodium intake correlates with psoriasis prevalence.
- To identify potential subgroups with salt-sensitive psoriasis.
Main Methods:
- Cross-sectional analysis of UK Biobank (nearly 500,000 participants) and NHANES (2393 participants) cohorts.
- Dietary sodium intake estimated via urine biomarkers and INTERSALT equation.
- Psoriasis diagnosis confirmed by ICD-10 code L40 or examination.
Main Results:
- Each 1g increase in 24-hour urine sodium correlated with an 18% increased odds of psoriasis in UK Biobank.
- Each 1g increase in self-reported dietary sodium correlated with a 47% increased odds of psoriasis in NHANES.
- No significant effect modification by age, sex, race, or comorbidities was consistently observed.
Conclusions:
- Elevated sodium intake is associated with psoriasis in population-based studies.
- Further clinical trials are warranted to explore the therapeutic potential of sodium reduction in managing psoriasis.
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