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Updated: May 30, 2025
Polymeric Microneedle Array Fabrication by Photolithography
Published on: November 17, 2015
Advances in adhesion of microneedles for bioengineering
Zhen Gu1, Kaiyu Song1, Heng An1
1School of Chemistry and Biological Engineering, Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, University of Science and Technology Beijing, Beijing 100083, P. R. China. guzhen@ustb.edu.cn.
Abstract:
Microneedles have provided promising platforms in various fields thanks to their safety, painlessness, minimal invasiveness and ease of operation. The excellent adhesion of microneedles is the key characteristic to achieve long-term and comfortable treatment. However, a complex environment, such as the roughness of skin, various bodily fluids in vivo, and the movement of the body, presents great challenges to the adhesion characteristics of microneedles. This review mainly reports the remarkable adhesion properties of microneedles based on interlocking by shape effects, chemical bonds, and suction forces. Firstly, the main mechanisms of adhesion and various types of microneedles are introduced, with an emphasis on the progress in adhesive microneedles. Combined with the preparation and application of microneedles, the challenges and future trends of adhesive microneedles are discussed.
