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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

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Related Experiment Video

Updated: Jun 21, 2026

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
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Published on: December 10, 2021

Allograft Use in Hand Surgery - 'Off the Shelf' Tendon Reconstruction: A Scoping Review.

Ahmed Hagiga1, Daphne Le Min Chiew2, Mohamed A Radhi3

  • 1Queen Victoria Hospital NHS Foundation Trust, East Grinstead, UK.

Plastic Surgery (Oakville, Ont.)
|January 29, 2025
PubMed
Summary

Tendon allografts show promise for upper limb reconstruction, particularly in severe trauma cases. While functional outcomes were mixed, patient satisfaction was high, though more research is needed on long-term efficacy and complications.

Keywords:
allograftstendontendon reconstructionupper limbs

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Last Updated: Jun 21, 2026

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Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine
  • Musculoskeletal Research

Background:

  • Tendon defects often require grafting for repair.
  • Allografts are common in knee ligament reconstruction but less established in upper limb tendon surgery.
  • A knowledge gap exists regarding allograft use in hand and upper limb tendon reconstruction.

Purpose of the Study:

  • To map current practices of tendon allograft utilization in upper limb reconstruction.
  • To identify existing literature on allograft use in hand surgery.
  • To pinpoint research gaps for future investigations into tendon allografts.

Main Methods:

  • A scoping review of MEDLINE and SCOPUS databases was performed.
  • Studies published in English up to June 2022 on upper limb tendon allografts were included.
  • Data extraction focused on patient demographics, outcomes, complications, and follow-up.

Main Results:

  • Six studies involving 116 patients and 148 allografts were identified.
  • Functional outcomes were rated 'good' or 'fair' in 72.9% of cases, with 25.8% rated 'poor'.
  • All assessed patients reported at least partial or fair satisfaction with the allograft results.

Conclusions:

  • Tendon allografts represent a potentially promising option for upper limb reconstruction, especially in complex trauma or salvage scenarios.
  • Further research is essential to evaluate efficacy, long-term results, and complications.
  • Comparative studies with autografts and standardized rehabilitation protocols are needed.