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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Dissociative Identity Disorder01:30

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Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
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Dissociative amnesia is a complex psychological condition that manifests as an inability to recall personal information, often tied to traumatic or stressful events. Unlike general amnesia, individuals with this condition retain the ability to perform routine activities and procedural tasks, such as operating a phone or navigating public transportation, yet experience profound gaps in autobiographical memory. These lapses may encompass significant life events, such as suicide attempts or...
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Updated: May 30, 2025

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Rare mixed dementia: A case report.

Xu-Hui Chen1,2, Wen Xia2, Jia-Bin Ma3

  • 1Department of Neurology, Peking University First Hospital, Beijing 100034, China.

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PubMed
Summary

This case highlights a patient with anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis and early Alzheimer's disease (AD) experiencing cognitive decline. Successful treatment improved cognitive function, suggesting a link between these conditions.

Area of Science:

  • Neuroimmunology
  • Neurodegenerative Diseases
  • Cognitive Impairment

Background:

Keywords:
Alzheimer’s diseaseAnti-leucine-rich glioma inactivated 1Case reportCognitive impairmentEncephalitis

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  • Autoimmune encephalitis (AE) is a rare neuroinflammatory condition linked to specific autoantibodies.
  • Anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis is a recently identified, treatable form of AE.
  • Alzheimer's disease (AD) is a common cause of dementia, with early stages like mild cognitive impairment (MCI) preceding typical symptoms.