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A preliminary study of linear accelerator-based spatially fractionated radiotherapy
Young Kyu Lee1, Yunji Seol1, Byeong Jin Kim1
1Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Frontiers in Oncology
|January 29, 2025
Summary
This study shows Lattice radiotherapy (LRT) is feasible with a medical linear accelerator and Millennium 120 multi-leaf collimator (MLC). Findings offer quantitative data for optimizing dose distribution and protecting normal tissues.
Area of Science:
- Medical Physics
- Radiation Oncology
Background:
- Lattice radiotherapy (LRT) offers potential for precise dose delivery.
- Implementing LRT requires understanding the impact of treatment parameters on dose distribution.
Purpose of the Study:
- To provide quantitative data for implementing Lattice radiotherapy (LRT) using a medical linear accelerator with a Millennium 120 multi-leaf collimator (MLC).
- To evaluate the effects of varying vertex diameters and separations on dose distribution, peak-to-valley dose ratio (PVDR), and normal tissue dose.
Main Methods:
- LRT plans were created in Eclipse v16.0 using a Virtual Water™ phantom.
- Vertex diameters (0.5-2.0 cm) and separations (1.0-5.0 cm) were systematically varied in a 3x3x3 lattice.
- Dose distribution, PVDR, normal tissue dose, monitor units (MU), and modulation complexity score (MCS) were analyzed.
Main Results:
- Optimal PVDR (<30%) was achieved with 5.0 cm separation.
- Increasing diameter/separation raised mean normal tissue dose but reduced high-dose volumes.
- MCS varied with diameter and separation, indicating plan complexity.
Conclusions:
- LRT implementation is technically feasible with the specified linear accelerator and MLC.
- The study provides a quantitative reference for optimizing LRT plans to achieve dose heterogeneity while sparing normal tissues.
