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Unveiling the link between chronic inflammation and cancer
Siddhant Tripathi1, Yashika Sharma1, Dileep Kumar2
1Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Pune, Maharashtra, 411038, India.
Metabolism Open
|January 29, 2025
Summary
Chronic inflammation promotes cancer development and spread by altering the tumor microenvironment and suppressing immune responses. Targeting inflammatory pathways offers a promising strategy for cancer therapy.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Chronic inflammation is increasingly recognized as a significant factor in cancer development and progression.
- Environmental stimuli can trigger inflammation, leading to oncogenic modifications within the tissue microenvironment.
- Sustained inflammation promotes carcinogenesis, angiogenesis, metastasis, and malignant cell survival.
Purpose of the Study:
- To review the multifaceted role of inflammation in cancer development and metastasis.
- To explore inflammation's impact on tumor progression, immune suppression, and therapy resistance.
- To examine current anti-inflammatory strategies for cancer treatment.
Main Methods:
- Literature review of molecular mechanisms linking inflammation to cancer.
- Analysis of inflammation's effects on tumor microenvironment and immune responses.
- Evaluation of existing anti-inflammatory therapeutic strategies.
Main Results:
- Inflammation promotes tumorigenesis and metastasis while suppressing anti-tumor immunity.
- Inflammation activates oncogenes and impairs host defenses in solid tumors like breast, lung, and liver cancer.
- Targeting inflammatory pathways is crucial for cancer treatment, impacting tumor progression and therapy resistance.
Conclusions:
- Inflammation is a key driver of cancer progression, metastasis, and immune evasion.
- Anti-inflammatory strategies, including NSAIDs, cytokine modulators, and STAT3 inhibitors, show therapeutic potential but require further research.
- Understanding the complex mechanisms linking inflammation to cancer is essential for developing targeted therapies for specific cancer subtypes.
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