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Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway
Fangqin You1, Diya Xie1, Cheng Li1
1Fuzhou First General Hospital Affiliated with Fujian Medical University Department of General Surgery FuzhouFujian China Department of General Surgery, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, Fujian, China.
Objective:
Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the first-line treatment of diabetes. The present work aimed to assess whether and how metformin exerts protective effects in DN.
Materials And Methods:
A DN rat model induced by streptozotocin (STZ) was established. Metformin was administered to examine its effect on sciatic nerve pathology, and the possible mechanisms involved in this process were explored.
Results:
Morphological damage was observed in sciatic nerve samples from diabetic animals, accompanied by decreased p-AMPK expression and increased LC-3 levels. Notably, metformin ameliorated the morphological changes in the sciatic nerve by downregulating autophagy via p-AMPK upregulation.
Conclusions:
These results indicate that metformin attenuates peripheral neuropathy in diabetic rats by regulating autophagy.
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