Acute and chronic effects of carbamyl glutamate on blood urea and ammonia

Carbamyl glutamate injected into normal rats produced no change in blood urea levels. Rats fed a high-protein diet or starved for 48 h had increased blood urea. Carbamyl glutamate injection induced a further increase in the levels of urea in their blood. Also, carbamyl glutamate administered in the drinking water of normal mice produced an increase in blood urea, which was accompanied by a decrease in blood ammonia. The application of these findings to the treatment of urea cycle enzymopathies is discussed.