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Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

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Related Experiment Video

Updated: Jul 16, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

[Dexamethasone suppression test in anorexia nervosa].

H Kuhs, H Mester

    European Archives of Psychiatry and Neurological Sciences
    |January 1, 1985
    PubMed
    Summary

    Pathological dexamethasone suppression test (DST) results in anorexia nervosa correlate with weight loss, regardless of bulimic symptoms or disease duration. This suggests secondary hypothalamic-pituitary-adrenal axis disturbances, not endogenous depression.

    Area of Science:

    • Endocrinology
    • Neuroscience
    • Psychiatry

    Context:

    • Anorexia nervosa is a complex eating disorder with significant physiological consequences.
    • The hypothalamic-pituitary-adrenal (HPA) axis is often implicated in stress responses and mood disorders.

    Purpose:

    • To investigate the relationship between dexamethasone suppression test (DST) results and clinical features in patients with anorexia nervosa.
    • To differentiate the HPA axis dysregulation in anorexia nervosa from endogenous depression.

    Summary:

    • A significant correlation was observed between pathological DST results and weight loss in anorexia nervosa patients (n=20).
    • Bulimic symptomatology did not alter this correlation, nor did the duration of the illness.
    • These findings suggest secondary regulatory disturbances of the HPA axis in anorexia nervosa, distinguishing it from endogenous depression where weight changes also affect DST results.

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    Published on: April 25, 2016

    Assessing Activity-based Anorexia in Mice
    08:26

    Assessing Activity-based Anorexia in Mice

    Published on: May 14, 2018

    Related Experiment Videos

    Last Updated: Jul 16, 2026

    Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
    07:46

    Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

    Published on: October 22, 2015

    Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
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    Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

    Published on: April 25, 2016

    Assessing Activity-based Anorexia in Mice
    08:26

    Assessing Activity-based Anorexia in Mice

    Published on: May 14, 2018

    Impact:

    • Provides evidence for HPA axis dysregulation as a secondary consequence of anorexia nervosa.
    • Helps differentiate the neuroendocrine profile of anorexia nervosa from that of endogenous depression.
    • Informs potential diagnostic and therapeutic strategies targeting the HPA axis in eating disorders.