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Updated: May 30, 2025
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Clinical validation of a biopsy-based six-gene signature prognostic for aggressive prostate cancer
Agnieszka Krzyzanowska1, Debra F Higgins2, Stephen Barron2
1Department of Translational Medicine, Division of Urological Cancers, Faculty of Medicine Lund University Lund Sweden.
Objectives:
This study aimed to clinically validate the six-gene prognostic molecular clinical risk score (MCRS) for the prediction of aggressive prostate cancer in diagnostic biopsy tissue.
Methods:
MCRS was evaluated in prostate biopsy tissue from a Swedish cohort of men with prostate cancer (UPCA, n = 100). The primary outcome of adverse pathology and secondary outcomes of high primary Gleason (≥G4) and high pathological T-stage (≥T3) were assessed by likelihood ratio statistics and area under the receiver operating characteristic curves from logistic regression models; time to biochemical recurrence was assessed by likelihood ratio statistics and C-indexes from Cox proportional hazard regression models.
Results:
Biopsy MCRS was significantly prognostic (p < 0.0001) and added significant prognostic value to clinico-pathological features for adverse pathology, high primary Gleason and high pathological T-stage (p < 0.0001). MCRS was prognostic for biochemical recurrence and added some, albeit non-significant, prognostic value to clinical risk stratifiers, which could reflect the low number of recurrence events in the cohort.
Conclusion:
Biopsy-based MCRS improves risk stratification over standard clinical and pathological information and optimises patient management after diagnosis of prostate cancer.
